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Alternative splicing of precursor mRNAs is a prevalent mechanism of gene regulation in higher eukaryotes. It generates enormous transcriptome diversity from a limited repertoire of protein-coding genes in the genome.

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Almost three quarters of multi-exon genes in the human genome are alternatively spliced. In this talk, I will describe the use of high-density exon tiling microarrays for global analysis of pre-mRNA alternative splicing. I will introduce a new computational method for analysis of alternative splicing using Affymetrix Exon 1.0 array data. By recognizing and correcting for microarray noise such as background and cross-hybridization, our method can identify differential alternative splicing events at a very low false positive rate. I�ll also discuss the impact of alternative splicing on the evolution of mammalian genomes, inferred from comparative analyses of transcriptome data from multiple species.
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